Expert Opinion: The influence of testosterone on cognitive functions in older men
Background
Older age comes with cognitive decline, with 40% of adults ³65 years experiencing age-associated memory loss.1 In addition, 20% of men >60 years have physiologically reduced serum testosterone levels.2 Prior observational studies demonstrated an association between low circulating testosterone and impaired cognitive performance.3,4 Two small trials yielded conflicting results, with one showing memory improvement with testosterone supplementation and one reporting negative findings.5,6 Hence, convincing evidence supporting testosterone intervention in this group is lacking. In this article, we discuss the largest trial to date evaluating the cognitive effects of testosterone treatment in older men.